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Structural Biology Facilities at the Department of Biochemistry

 

TECAN: Freedom EVO 100 (by Tecan Group Ltd) Liquid Handling Platform – creation of customised crystallisation screens and dispensation of commercial crystallisation kits into a variety of crystallisation plates.

MOSQUITO: MOSQUITO CRYSTAL (by TTPLabtech Ltd.) Protein Crystallisation System – high-speed liquid dispensing system for automated setup of macromolecular crystallisation trials. Uses disposable pipette tips. Video.

DRAGONFLY: DRAGONFLY (by TTPLabtech Ltd.) Screen optimiser – enables complex assay gradients or optimisation screens to be rapidly and accurately prepared, even with viscous liquids, while illuminating cross-contamination. Video.

ROCK IMAGER 1000 (by Formulatrix, Inc) is an automated imaging system for protein crystallisation. Incubates and captures high quality images of up to 1000 microplates on a user-defined schedule. The system also includes the UV modification allowing users to easily discover which crystals are salt and which are protein.

Other Crystallisation Equipment:

Centeo TG40 System (by Centeo Biosciences) – designed to enable temperature optimisation for vapour phase diffusion protein crystallisation experiments. The Facility currently has 5 of those systems.

A number of various stereo microscopes including two newly acquired SZX16 (by Olympus Ltd) are available for the Facility users. One of the key features of SZX16 includes the use of white LED illumination with average lifetime of 12,800 hours.